Manusela National Park is very representative of the type of coastal ecosystem, swamp forest, lowland rain forest and mountain rain forests in Maluku. Vegetation types found in this national park is the mangrove, beach forest, swamp, creek, pamah tropical rain forest, montane forests, and sub-alpine forest.
Some plant species in national parks, among others tancang (Bruguiera sexangula), mangrove (Rhizophora acuminata), fire-fire (Avicennia sp.), Lime (Dryobalanops sp.), Pulai (Alstonia scholaris), almond (Terminalia catappa), pandanus (Pandanus sp.), meranti (Shorea selanica), benuang (Octomeles sumatrana), matoa / lotion (Pometia pinnata), eucalyptus (Melaleuca leucadendron), various kinds of orchids, and ferns are endemic (Chintea binaya).
Approximately 117 bird species found in Manusela National Park, where 14 of them endemic species such as (Lorius garrulus), nape parrot purple / black-headed parrot (L. domicella), Seram cockatoo (Cacatua moluccensis), king prawn (Halcyon lazuli and H . sancta), Seram honey big bird (Philemon subcorniculatus), and the king parrot / parrot ambon (Alisterus amboinensis).
Sinister parrot is one of the island of Maluku endemic wildlife, its existence threatened with extinction in the wild due to poaching, habitat destruction and depreciation. Other wildlife in this national park is the deer (Cervus timorensis moluccensis), polecat (Phalanger orientalis orientalis), soa-soa (Hydrosaurus amboinensis), wild boar (Sus celebensis), mongoose (Pardofelis marmorata), panama lizard (Tiliqua gigas gigas), dugongs (Dugong dugon), green turtle (Chelonia mydas), and various species of butterflies.
There are rivers flowing, with steep topography configuration that six of the mountain / hill with Mount Binaya the highest (± 3027 m asl).
Villagers Manusela, Ilena Maraina, Selumena, and Kanike, an enclave within the National Park area Manusela. Community has been long in these villages, and believe that the mountains are located in national parks can provide the spirit and the protection of their lives. Their trust will indirectly help to maintain and preserve the national parks.